“Patient-Centered Clinical Research Coordinating Center Program (PACEN)” is the largest investigator-initiated research program funded by the Korean government for public interest. It supports practical research for comparative assessment or evidence-generation of health technologies used in healthcare systems, and it aims to usefully transfer the research results to practice, policy, or healthcare services. PACEN seeks to solve the matter health systems are facing and to improve the quality of health services with the perspectives of patient and the public through producing high-quality evidence. It carries out the following tasks to successfully achieve the program purpose as above. 1) Strengthen the patient-centerdness in research by identifying unmet needs of patients and the public and by reflecting them in priority settings, outcomes evaluation, and dissemination. 2) Involve and integrate healthcare stakeholders including patients, providers, policymakers, etc. 3) Support to generate real-world evidence and to transfer it to clinical and policy decision-making. 4) Establish a public database system that systematically manages, links, and recycles clinical research data. Through an 8-year (2019~2026) program, we expect to reach the following accomplishments. First, we obtain standardized real-world data of more than 160,000 cases through a clinical research management platform. Also, we facilitate the secondary use of the data, as well as the expansion of the database through supporting the integration of it with other data. Second, we support 380 evidence-generating studies to optimize patient outcomes with health, cost-effectiveness, and quality of life. Additionally, about 1,100 scientific papers and 100 clinical practice guidelines are expected to be published. Third, we process the research results and produce easy-to-understand health information so that the results can be effectively transferred to and used by the public. We support the public to make informed-clinical decisions and resolve their health problems. Lastly, we support clinical appraisals of research results where various stakeholders participated and generated their perspectives on the results, reaching a consensus. Therefore, we raise the availability and the acceptability of research results, effectively transfer research to policy, and, finally, contribute to the evidence-based healthcare system.