Living Evidence to Inform Health Decisions Framework (LE-IHD): A practical interactive framework based tool to guide the incorporation of Living Evidence in the development of knowledge transfer products

Date & Time
Wednesday, September 6, 2023, 2:55 PM - 3:05 PM
Location Name
Session Type
Oral presentation
Living syntheses and prospective meta-analyses
Oral session
Living evidence and prospective meta-analyses
Rojas-Reyes MX1, Bendersky J2, Auladell-Rispau A3, Verdugo F4, Rada G5, Alonso-Coello P1, Urritia G6
1Biomedical Research Institut Sant Pau (IIB Sat Pau), Barcelona., Spain
2Iberoamerican Cochrane Centre, Barcelona, Catalunya, Spain; Universitat Autònoma de Barcelona, Barcelona, Catalunya, Spain., Chile
3PhD Program in Biomedical Research Methodology and Public Health. Universitat Autònoma de Barcelona, Barcelona, Catalunya,, Spain
4Epistemonikos Foundation, Chile
5Epistemonikos Foundation. Pontificia Universidad Catolica., Chile
6Iberoamerican Cochrane Center. Biomedical Research Institut Sant Pau (IIB Sat Pau), Barcelona., Spain

Background: Knowledge transfer [KT] products used to inform health decisions should be based on the most current evidence. A framework based practical tool for incorporating the Living Evidence [LE] model can address this need.
Objectives: To define a framework to guide the incorporation of the LE model in the development of KT products. To develop a framework-based practical tool to support the LE synthesis planning, conduction, evidence monitoring, and reporting.
Methods:The definition of the framework followed an iterative process. Complementary steps were: 1. Systematic review of methodological articles; 2. Two brainstorming meetings; 3.Drafting framework initial version; 4. Expert consultation; 5.User testing; 6.Refining the framework and development of final version; 7. Framework validation in a pilot study.
Results: Twelve methodological articles were identified and used to generate a checklist of key aspects to be included in the guidance framework . The list was distributed among the core team prior to brainstorming meetings. The core team developed the preliminary framework draft that underwent testing among 10 potential users from Cochrane centers and HTA agencies; concurrently, it was presented to experts advisors working on LE. The comments and suggestions collected from users and experts were used to redefine the framework. Its final version was structured into four sections according to the time they are applied during the evidence synthesis process, with a set of guidance questions in each section. This version was tested and evaluated by working groups of HTA agencies and guideline-developers for the planning and conduction of LE synthesis of relevant questions for real-life decision-making. The framework assessment included a survey and in-depth interviews with study participants. Results were taken into account for developing the web-based interactive tool (LE-IHD framework) and its handbook which underwent final experts review prior to launching the tool for its use. Available at:
Conclusions: The process followed for the framework development, the participation of LE experts and its validation among key potential users experts, allow us to conclude that this tool has the desired quality to support the synthesis of LE and guide its way to inform health decisions.
Patient, public and/or healthcare consumer involvement: