We all need data we can trust. Cochrane policy requires that studies with serious research integrity problems, including fraudulent data, be excluded from Cochrane Reviews.  This plenary will explore the scope and root causes of the problem of fraudulent and problematic research.  Solutions to identifying and preventing the publication of research with serious research integrity problems will be discussed.  The international panel of speakers will offer perspectives from a variety of disciplines on paper mills, tools to identify fraudulent studies, and what systematic reviewers and journals can do to improve research integrity.  There will be ample time for audience participation in the discussion of proposed solutions.